The Los Angeles Pediatric Research Integrating Sensor Monitoring Systems (LA PRISMS) Center develops mobile health (mHealth) technologies for the scientific understanding and self-management of pediatric asthma. As part of a collaboration between UCLA and USC under the NIH's PRISMS community, this collaborative effort focuses on the creation of an innovative end-to-end infrastructure for pediatric sensor-based health monitoring. To answer the question "what if you could predict for a specific asthma patient the potential of an asthma attack, and thus mitigate if not prevent the event from occurring?", the Biomedical REAl-Time Health Evaluation for pediatric asthma (BREATHE) platform was developed. This system provides an extensible software infrastructure to communicate with a growing array of physiological and environmental sensors, and places the data into context to understand the patient's state. Through the use of sensors, smartphones, smartwatches, cloud-based servers, and data warehouses, the infrastructure developed defined the application programming interfaces for data exchange, secured all aspects of data collection and transmission to ensure privacy and security of health information, while optimizing the power usage on the sensors and smart devices.